PLOS-CB features works of exceptional significance that further our understanding of living systems at all scales; from molecules and cells, to patient populations and ecosystems; through the application of computational methods. Readers include life and computational scientists, who can take the important findings presented here to the next level of discovery. Research articles must be declared as belonging to one of the following categories: General, Methods or Software. Software articles form a specific sub-category. More information about Software articles can be found in the submission guidelines. Research articles should model aspects of biological systems, demonstrate both methodological and scientific novelty, and provide profound new biological insights.

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